Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.74 |
| ▸ | FNTB | P49356 | 13/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.59 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161541 | 0.99 | FNTA (0.75) | FNTAFNTBCYP3A4PGGT1B | |
| SCHEMBL6166742 | 0.93 | FNTA (0.72) | FNTAFNTBCYP3A4PGGT1B | |
| SCHEMBL6843800 | 0.85 | FNTA (1.00) | FNTAFNTBCYP3A4PGGT1B | |
| SCHEMBL11947168 | 0.85 | FNTA (1.00) | FNTAFNTBCYP3A4PGGT1B | |
| SCHEMBL7665450 | 0.85 | FNTA (0.72) | FNTAFNTBCYP3A4PGGT1B | |
| Tipifarnib SCHEMBL23633189 | 0.84 | FNTA (0.80) | FNTAFNTBCYP3A4PGGT1B | |
| Tipifarnib SCHEMBL8097 | 0.84 | FNTA (0.80) | FNTAFNTBCYP3A4PGGT1B | |
| Tipifarnib SCHEMBL22772860 | 0.84 | FNTA (0.80) | FNTAFNTBCYP3A4PGGT1B | |
| Tipifarnib SCHEMBL21544535 | 0.84 | FNTA (0.80) | FNTAFNTBCYP3A4PGGT1B | |
| (S)-Tipifarnib SCHEMBL4429738 | 0.84 | FNTA (0.80) | FNTAFNTBCYP3A4PGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107962-B1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6495564-B1 | SUCH AS 3-(6-((4-CHLORO-PHENYL)-HYDROXY-(3-METHYL-3H-IMIDAZOL-4-YL)-METHYL)-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLIN-4-YL)-BENZALDEHYDE O-METHYL-OXIME; INHIBITING ABNORMAL CELL GROWTH | PFIZER INC. | 2002-12-17 | — | — | US | disclosed |
| EP-1107962-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012498-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-03-09 | — | — | WO | disclosed |