SCHEMBL6162071

SCHEMBL6162071

CCCCCC(CC)OS(C)(=O)=O

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.39
ALDH1A1 P00352 1/20 0.36
CA1 P00915 4/20 0.33
CA2 P00918 4/20 0.33
CA9 Q16790 4/20 0.33
SMPD1 P17405 3/20 0.33
OPRM1 P35372 1/20 0.33
NR1I2 O75469 1/20 0.33
FDPS P14324 1/20 0.33
GPR84 Q9NQS5 2/20 0.32
ZDHHC7 Q9NXF8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7352723 0.98 TP53 (0.38) TP53CA1CA2CA9SMPD1
SCHEMBL28870861 0.98 TP53 (0.38) TP53CA1CA2CA9SMPD1
SCHEMBL14779809 0.94 ALDH1A1 (0.37) TP53ALDH1A1CA1CA2
SCHEMBL6307966 0.91 TP53 (0.42) TP53ALDH1A1CA1CA2CA9
SCHEMBL13499764 0.89 TP53 (0.41) TP53CA1CA2CA9SMPD1
SCHEMBL3488909 0.89 TP53 (0.41) TP53CA1CA2CA9SMPD1
SCHEMBL15211949 0.89 TP53 (0.41) TP53CA1CA2CA9SMPD1
SCHEMBL3080295 0.89 TP53 (0.41) TP53CA1CA2CA9SMPD1
SCHEMBL13258344 0.88 TP53 (0.39) TP53ALDH1A1CA1CA2CA9
SCHEMBL3858248 0.86 TP53 (0.38) TP53CA1CA2CA9SMPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118290403-A Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-05 CN disclosed
WO-2023241627-A1 CDK8/19 DUAL INHIBITORS AND METHODS OF USE THEREOF INSILICO MEDICINE IP LIMITED (CN) 2023-12-21 WO disclosed
EP-3877381-A1 BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF Lynk Pharmaceuticals Co. Ltd. (CN) 2021-09-15 EP disclosed
WO-2020119819-A1 BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2020-06-18 WO disclosed
EP-1102751-A4 NOVEL BI- AND TRI-CYCLIC AZA COMPOUNDS AND THEIR USES UNIV GEORGETOWN (US) 2005-06-22 EP disclosed
EP-0683781-B1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE METABASIS THERAPEUTICS INC (US) 2004-04-21 EP disclosed
EP-1102751-A1 NOVEL BI- AND TRI-CYCLIC AZA COMPOUNDS AND THEIR USES Georgetown University (US) 2001-05-30 EP disclosed
WO-2000007994-A1 NOVEL BI- AND TRI-CYCLIC AZA COMPOUNDS AND THEIR USES GEORGETOWN UNIVERSITY (US) 2000-02-17 WO disclosed
US-5731432-A Inhibitors of adenosine monophosphate deaminase GENSIA SICOR INC. (US) 1998-03-24 US disclosed
EP-0683781-A4 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. GENSIA PHARMA (US) 1997-05-28 EP disclosed
EP-0683781-A1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE GENSIA PHARMACEUTICALS, INC. (US) 1995-11-29 EP disclosed
WO-1994018200-A1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE GENSIA, INC. (US) 1994-08-18 WO disclosed
US-4920221-A CENTRAL NERVOUS SYSTEM ACTIVE AGENTS PFIZER INC. (US) 1990-04-24 US disclosed
US-4642373-A Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents PFIZER INC. (US) 1987-02-10 US disclosed
US-4476131-A ANTIEMETICS, ANALGESICS PFIZER INC. (US) 1984-10-09 US disclosed
US-4473704-A ANALGESICS, ANTIEMETICS PFIZER INC. (US) 1984-09-25 US disclosed