Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.73 |
| ▸ | DPP8 | Q6V1X1 | 13/20 | 0.73 |
| ▸ | DPP9 | Q86TI2 | 13/20 | 0.73 |
| ▸ | DPP7 | Q9UHL4 | 13/20 | 0.73 |
| ▸ | FAP | Q12884 | 10/20 | 0.70 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182020 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5713152 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL27452954 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL2195630 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5713150 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7298604 | 0.85 | DPP4 (0.80) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL24989201 | 0.85 | DPP4 (0.69) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7375090 | 0.85 | ACE (0.70) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL3726263 | 0.85 | ACE (0.70) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5900809 | 0.85 | ACE (0.70) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |