Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11605746 | 0.82 | CYP1A2 (0.75) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL11252585 | 0.79 | HTT (0.61) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL11252528 | 0.78 | GAA (0.70) | ALDH1A1HTTGAATHRBHPGD | |
| SCHEMBL4168758 | 0.77 | ALDH1A1 (0.67) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL16366911 | 0.77 | ALDH1A1 (0.51) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL141474 | 0.77 | GAA (0.58) | ALDH1A1HSD17B10HTTGAATHRB | |
| SCHEMBL4341824 | 0.76 | CYP1A2 (0.64) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL8808326 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL11651781 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 | |
| SCHEMBL30447073 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CYP1A2CYP3A4HSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210335-B1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |