Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | KIF5B | P33176 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162721 | 1.00 | KDR (0.62) | KDRCSF1RPDGFRAMETAURKA | |
| SCHEMBL6165440 | 0.86 | KDR (0.66) | KDRCSF1RPDGFRAMETAURKA | |
| SCHEMBL22165293 | 0.83 | KDR (0.63) | KDRCSF1RPDGFRAMETAURKA | |
| SCHEMBL28468402 | 0.80 | KDR (0.66) | KDRCSF1RPDGFRAMETAURKA | |
| SCHEMBL5824501 | 0.80 | KDR (0.66) | KDRCSF1RPDGFRAFLT4RET | |
| SCHEMBL30447769 | 0.80 | KDR (0.66) | KDRCSF1RPDGFRAMETAURKA | |
| SCHEMBL6009208 | 0.79 | KDR (0.83) | KDRCSF1RPDGFRAMETFLT1 | |
| SCHEMBL1097832 | 0.79 | PDGFRB (0.67) | KDRCSF1RPDGFRAFLT4PDGFRB | |
| SCHEMBL18158553 | 0.79 | KDR (0.70) | KDRCSF1RPDGFRAFLT4RET | |
| SCHEMBL4365791 | 0.79 | KDR (0.74) | KDRCSF1RPDGFRAFLT4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218357-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-06 | — | — | EP | claimed |