Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 4/20 | 0.54 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162705 | 0.86 | KDR (0.62) | KDRPDGFRACSF1RFLT4FLT1 | |
| SCHEMBL6162721 | 0.86 | KDR (0.62) | KDRPDGFRACSF1RFLT4FLT1 | |
| SCHEMBL6162829 | 0.81 | KDR (0.70) | KDR | |
| SCHEMBL6162952 | 0.81 | KDR (0.70) | KDR | |
| SCHEMBL30448369 | 0.80 | KDR (0.69) | KDRPDGFRACSF1RFLT4RAF1 | |
| SCHEMBL28464530 | 0.80 | KDR (0.69) | KDRPDGFRACSF1RFLT4RAF1 | |
| SCHEMBL22165293 | 0.79 | KDR (0.63) | KDRPDGFRACSF1RFLT4AURKA | |
| SCHEMBL22164824 | 0.77 | PDGFRB (0.64) | KDRPDGFRACSF1RFLT4PDGFRB | |
| SCHEMBL5824501 | 0.76 | KDR (0.66) | KDRPDGFRACSF1RFLT4BRAF | |
| SCHEMBL26791130 | 0.76 | FDPS (0.62) | FDPSMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218357-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-06 | — | — | EP | claimed |