SCHEMBL6162880

SCHEMBL6162880

CCC(Oc1ccc(OCc2cc(-c3ccc(C(F)(F)F)cc3)oc2C(F)(F)F)cc1C)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 18/20 0.47
PPARA Q07869 3/20 0.47
PTGDR2 Q9Y5Y4 1/20 0.43
PTGER4 P35408 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5860856 0.92 PPARD (0.48) PPARDPPARAPTGDR2
SCHEMBL5862068 0.88 PPARD (0.52) PPARDPPARAPTGDR2
SCHEMBL5861885 0.85 PPARD (0.49) PPARDPPARAPTGDR2
SCHEMBL5861093 0.84 PPARD (0.66) PPARDPPARA
SCHEMBL6164372 0.84 PPARA (0.39) PPARDPPARAPTGDR2
SCHEMBL6166462 0.83 PPARD (0.60) PPARDPPARA
SCHEMBL5860715 0.81 PPARD (0.51) PPARDPPARAPTGDR2
SCHEMBL5861876 0.80 PTGER4 (0.51) PPARDPPARAPTGER4
SCHEMBL5862044 0.79 PPARD (0.48) PPARDPPARA
SCHEMBL5861095 0.79 PPARA (0.50) PPARDPPARAPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392674-B1 FURAN AND THIOPHENE DERIVATIVES THAT ACTIVATE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS SMITHKLINE BEECHAM CORP (US) 2005-08-10 EP disclosed