Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.72 |
| ▸ | HTR2C | P28335 | 4/20 | 0.67 |
| ▸ | HTR2B | P41595 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076217 | 0.84 | PNMT (1.00) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL5682410 | 0.82 | PNMT (0.97) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL1241257 | 0.81 | HTR2C (0.61) | PNMTHTR2CHTR2BSMN1; SMN2ADRA2A | |
| SCHEMBL1244028 | 0.81 | PNMT (0.61) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL25590941 | 0.81 | PNMT (0.73) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL2401511 | 0.79 | PNMT (0.71) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL17056235 | 0.79 | PNMT (1.00) | PNMTHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL10704048 | 0.78 | SMN1; SMN2 (0.79) | PNMTHTR2CHTR2BSMN1; SMN2HTR6 | |
| SCHEMBL17258825 | 0.78 | PNMT (0.57) | PNMTHTR2CHTR2BSMN1; SMN2ADRA2A | |
| SCHEMBL31528383 | 0.78 | PNMT (0.57) | PNMTHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |