Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | AKT2 | P31751 | 1/20 | 0.56 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25222625 | 0.85 | HDAC8 (0.67) | HDAC8AKT1AKT2AKT3PNMT | |
| SCHEMBL6161830 | 0.84 | OPRD1 (0.65) | HDAC8DPP7AKT1AKT2AKT3 | |
| SCHEMBL3133533 | 0.84 | OPRD1 (0.65) | HDAC8DPP7AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL25271343 | 0.84 | HDAC8 (0.65) | HDAC8AKT1AKT2AKT3PNMT | |
| Hydrochloric Acid SCHEMBL25224933 | 0.84 | HDAC8 (0.65) | HDAC8AKT1AKT2AKT3PNMT | |
| Hydrochloric Acid SCHEMBL6166049 | 0.83 | DPP7 (0.67) | DPP7AKT1AKT2AKT3CYP51A1 | |
| Hydrochloric Acid SCHEMBL6166042 | 0.83 | DPP7 (0.67) | DPP7AKT1AKT2AKT3CYP51A1 | |
| Hydrochloric Acid SCHEMBL6163295 | 0.83 | HDAC8 (0.63) | HDAC8DPP7AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6163301 | 0.83 | HDAC8 (0.63) | HDAC8DPP7AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6165745 | 0.83 | HDAC8 (0.63) | HDAC8DPP7AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |