Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27354055 | 1.00 | CTSS (0.53) | CTSSCTSKKLK5CTSLCTSB | |
| SCHEMBL2307387 | 0.90 | ACE (0.58) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL2307394 | 0.90 | ACE (0.58) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL3728427 | 0.90 | ACE (0.58) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL31407374 | 0.90 | ACE (0.58) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL5028161 | 0.89 | CTSS (0.53) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL9107541 | 0.89 | CTSS (0.53) | CTSSCTSKCTSLCTSBBCL2 | |
| SCHEMBL1826757 | 0.86 | CTSS (0.69) | CTSSCTSKKLK5CTSLCTSB | |
| SCHEMBL10033679 | 0.86 | CTSS (0.69) | CTSSCTSKKLK5CTSLCTSB | |
| SCHEMBL2802961 | 0.86 | CTSS (0.69) | CTSSCTSKKLK5CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| CN-1071325-C | Thiol derivatives having metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 2001-09-19 | — | — | CN | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| CN-1206411-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 1999-01-27 | — | — | CN | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |