Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055828 | 0.69 | CRBN (0.37) | ESR2 | |
| SCHEMBL11880678 | 0.67 | OR51E2 (0.32) | ESR2 | |
| SCHEMBL3699545 | 0.64 | — | — | |
| SCHEMBL7389648 | 0.60 | TLR4 (0.32) | — | |
| SCHEMBL15994991 | 0.60 | — | — | |
| SCHEMBL11181948 | 0.60 | TLR4 (0.47) | ESR2 | |
| SCHEMBL22614826 | 0.60 | TLR4 (0.34) | ESR2 | |
| SCHEMBL9213105 | 0.59 | TLR4 (0.39) | ESR2 | |
| SCHEMBL18204969 | 0.58 | — | — | |
| SCHEMBL5201714 | 0.58 | TLR4 (0.55) | ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |