Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10757593 | 0.86 | CYP2C9 (0.83) | CYP2C9ALDH1A1TRPV1POLBRAB9A | |
| SCHEMBL6163182 | 0.85 | DHODH (0.65) | CYP2C9ALDH1A1TRPV1POLBRAB9A | |
| SCHEMBL6162171 | 0.85 | POLB (0.58) | CYP2C9ALDH1A1POLBGAAMOK | |
| SCHEMBL10761462 | 0.85 | CYP2C9 (0.86) | CYP2C9ALDH1A1TRPV1POLBRAB9A | |
| SCHEMBL13253403 | 0.84 | KDM4E (0.71) | CYP2C9ALDH1A1TRPV1POLBGAA | |
| SCHEMBL1898306 | 0.82 | HSD17B10 (0.86) | CYP2C9ALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL13957864 | 0.80 | HSD17B10 (0.69) | CYP2C9ALDH1A1LMNASMN1; SMN2PTGES | |
| SCHEMBL6163587 | 0.80 | DHODH (0.50) | CYP2C9ALDH1A1TRPV1POLBGAA | |
| SCHEMBL6163667 | 0.80 | DHODH (0.50) | CYP2C9ALDH1A1TRPV1POLBGAA | |
| SCHEMBL6164215 | 0.80 | DHODH (0.50) | CYP2C9ALDH1A1TRPV1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337523-B1 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORP (US) | 2005-10-19 | — | — | EP | claimed |
| US-20040048867-A1 | 2,4-Substituted pyridine derivatives | NEUROGEN CORPORATION | 2004-03-11 | — | — | US | claimed |
| EP-1337523-A2 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2003-08-27 | — | — | EP | claimed |
| US-20020161008-A1 | 2,4-Substituted pyridine derivatives | NEUROGEN CORPORATION | 2002-10-31 | — | — | US | claimed |
| WO-2002014269-A2 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2002-02-21 | — | — | WO | claimed |
| US-6559163-B2 | Agonists, antagonists or inverse agonists for GABAA brain receptors; useful in diagnosis and treatment of anxiety, depression | NEUROGEN CORPORATION | 2003-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161008-A1 | 2,4-Substituted pyridine derivatives | GABARAP, GABRB1, GABARAPL1 | CYP2C9 422/4885ALDH1A1 922/4885TRPV1 1234/4885 |
| US-20040048867-A1 | 2,4-Substituted pyridine derivatives | GABARAP, GABRB1, GABARAPL1 | CYP2C9 422/4885ALDH1A1 922/4885TRPV1 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.