GABRB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20
SCHEMBL9273	0.53	9/20
SCHEMBL8931	0.51	9/20
SCHEMBL8932	0.51	9/20
SCHEMBL9163	0.58	8/20
SCHEMBL8941	0.54	8/20
SCHEMBL8047	0.56	7/20

Clinical trials — most relevant to GABRB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.	PHASE4	COMPLETED
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex	PHASE4	COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
Effects of Baclofen on Presynaptic Inhibition in Humans	PHASE2	WITHDRAWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
Physiologic Effects of Topiramate on Cognition	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders	nan	RECRUITING
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
L-arginine add-on Therapy in Patients With Schizophrenia	nan	COMPLETED
Pharmacokinetics Study of Gamma-aminobutyric Acid	nan	COMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain	nan	RECRUITING
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression	nan	COMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRB1 binder may also engage these)

Protein	Name	Similarity
P15431	—	1.000	P15431 →
P50571	—	1.000	P50571 →
P08220	—	1.000	P08220 →
P63079	—	1.000	P63079 →
GABRB2	Gamma-aminobutyric acid receptor subunit beta-2	1.000	landscape →
P63137	—	1.000	P63137 →
P19019	—	0.999	P19019 →
P0C2W5	—	0.997	P0C2W5 →
GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	0.997	landscape →
P63080	—	0.995	P63080 →
P63138	—	0.993	P63138 →
D1LYT2	—	0.993	D1LYT2 →
P18508	—	0.975	P18508 →
P21548	—	0.974	P21548 →
GABRA5	Gamma-aminobutyric acid receptor subunit alpha-5	0.971	landscape →
Q5REA1	—	0.970	Q5REA1 →
P19969	—	0.969	P19969 →
GABRG2	Gamma-aminobutyric acid receptor subunit gamm	0.969	landscape →
P22300	—	0.968	P22300 →
Q8BHJ7	—	0.968	Q8BHJ7 →
P27681	—	0.968	P27681 →
P22723	—	0.967	P22723 →
P28473	—	0.966	P28473 →
P62812	—	0.965	P62812 →
P62813	—	0.965	P62813 →
Q4R534	—	0.964	Q4R534 →
Q08E50	—	0.963	Q08E50 →
Q5R6B2	—	0.962	Q5R6B2 →
GABRG3	Gamma-aminobutyric acid receptor subunit gamm	0.962	landscape →
P08219	—	0.961	P08219 →