Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.61 |
| ▸ | CTSK | P43235 | 2/20 | 0.61 |
| ▸ | ACE | P12821 | 5/20 | 0.50 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163670 | 1.00 | CTSS (0.61) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL4600435 | 0.88 | CTSS (0.76) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL613640 | 0.88 | CTSS (0.76) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL4122289 | 0.88 | CTSS (0.76) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL29401990 | 0.88 | CTSS (0.76) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL17137921 | 0.84 | CTSS (0.77) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL17137918 | 0.84 | CTSS (0.77) | CTSSCTSKACEMMECPA1 | |
| SCHEMBL5253098 | 0.84 | ACE (0.70) | CTSSCTSKACESCN9ACTSL | |
| SCHEMBL5253093 | 0.84 | ACE (0.70) | CTSSCTSKACESCN9ACTSL | |
| SCHEMBL10174744 | 0.84 | ACE (0.70) | CTSSCTSKACESCN9ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |