Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.40 |
| ▸ | ITGAV | P06756 | 5/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | SI | P14410 | 7/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.39 |
| ▸ | HAT1 | O14929 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160985 | 0.96 | MGAM (0.42) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6169546 | 0.94 | ITGB3 (0.35) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6698561 | 0.94 | ITGB3 (0.37) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6697764 | 0.93 | MGAM (0.42) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6701591 | 0.93 | MGAM (0.41) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6701434 | 0.93 | MGAM (0.41) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6696461 | 0.93 | FFAR1 (0.37) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6692554 | 0.93 | MGAM (0.37) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6696924 | 0.93 | MGAM (0.45) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Trifluoroacetic Acid SCHEMBL6701400 | 0.92 | MGAM (0.45) | ITGB3ITGAVITGB1ITGB6ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254133-B9 | INDOL-3-YL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2005-09-07 | — | — | EP | disclosed |
| EP-1254133-B1 | INDOL-3-YL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-20040138284-A1 | Indol-3-yl derivatives | WIESNER MATTHIAS | 2004-07-15 | — | — | US | disclosed |
| US-6743810-B2 | INTEGRIN INHIBITORS; TUMORS, OSTEOPOROSIS, OSTEOLYTIC DISEASES, SUPPRESSING ANGIOGENESIS, ANTITHROMBOTIC | MERCK PATENT GMBH (DE) | 2004-06-01 | — | — | US | disclosed |
| US-20030045728-A1 | Liberating 3-substituted indole compound from one of its functional derivatives by treatment with a solvolyzing or hydrogenating agent, amidation, saponification, alkylation or acylation, or salt formation | MERCK PATENT GMBH (DE) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045728-A1 | Liberating 3-substituted indole compound from one of its functional derivatives by treatment with a solvolyzing or hydrogenating agent, amidation, saponification, alkylation or acylation, or salt formation | IGF1R, IDO1, ITGB3 | ITGB3 3/4885ITGAV 67/4885ITGB1 4/4885 |
| US-20040138284-A1 | Indol-3-yl derivatives | ITGB3, ITGB1, IGF1R | ITGB3 1/4885ITGAV 35/4885ITGB1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.