Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 16/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | PLD2 | O14939 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162348 | 1.00 | CALCRL (0.53) | CALCRLCYP3A4HSD11B1PLD2PLD1 | |
| SCHEMBL6161678 | 0.88 | CALCRL (0.47) | CALCRLCYP3A4HSD11B1PLD2PLD1 | |
| SCHEMBL6161686 | 0.88 | CALCRL (0.47) | CALCRLCYP3A4HSD11B1PLD2PLD1 | |
| SCHEMBL6164981 | 0.81 | CALCRL (0.75) | CALCRLCYP3A4HSD11B1RAMP1 | |
| SCHEMBL8409918 | 0.80 | HSD11B1 (0.45) | CALCRLCYP3A4HSD11B1PLD2PLD1 | |
| Hydrochloric Acid SCHEMBL6162097 | 0.80 | CALCRL (0.74) | CALCRLCYP3A4HSD11B1RAMP1 | |
| Hydrochloric Acid SCHEMBL6161925 | 0.80 | CALCRL (0.74) | CALCRLCYP3A4HSD11B1RAMP1 | |
| SCHEMBL6161840 | 0.80 | CALCRL (0.56) | CALCRLCYP3A4HSD11B1RAMP1 | |
| SCHEMBL6161834 | 0.80 | CALCRL (0.56) | CALCRLCYP3A4HSD11B1RAMP1 | |
| SCHEMBL6164868 | 0.79 | CALCRL (0.60) | CALCRLCYP3A4HSD11B1RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | claimed |
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |