Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165032 | 1.00 | HCRTR1 (0.47) | HCRTR1HCRTR2POLBSPHK2HSP90AA1 | |
| SCHEMBL6167631 | 1.00 | HCRTR1 (0.47) | HCRTR1HCRTR2POLBSPHK2HSP90AA1 | |
| SCHEMBL6164654 | 0.90 | RAB9A (0.53) | HCRTR1HCRTR2POLBSPHK2HSP90AA1 | |
| SCHEMBL6163166 | 0.90 | RAB9A (0.53) | HCRTR1HCRTR2POLBSPHK2HSP90AA1 | |
| SCHEMBL6162969 | 0.90 | RAB9A (0.53) | HCRTR1HCRTR2POLBSPHK2HSP90AA1 | |
| SCHEMBL6163699 | 0.88 | POLB (0.55) | HCRTR1HCRTR2POLBHSP90AA1RAB9A | |
| SCHEMBL6165715 | 0.88 | POLB (0.55) | HCRTR1HCRTR2POLBHSP90AA1RAB9A | |
| SCHEMBL6163817 | 0.88 | POLB (0.55) | HCRTR1HCRTR2POLBHSP90AA1RAB9A | |
| SCHEMBL6165793 | 0.85 | HCRTR1 (0.51) | HCRTR1HCRTR2POLBRAB9AKDM4E | |
| SCHEMBL6163609 | 0.85 | HCRTR1 (0.51) | HCRTR1HCRTR2POLBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337523-B1 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORP (US) | 2005-10-19 | — | — | EP | claimed |
| US-6559163-B2 | Agonists, antagonists or inverse agonists for GABAA brain receptors; useful in diagnosis and treatment of anxiety, depression | NEUROGEN CORPORATION | 2003-05-06 | — | — | US | disclosed |