Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.58 |
| ▸ | HCK | P08631 | 3/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 13/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163117 | 0.91 | RAF1 (0.56) | MAPK14MAPK12RAF1MAPK13MAPK11 | |
| SCHEMBL6164402 | 0.88 | RAF1 (0.54) | MAPK14MAPK12RAF1MAPK13MAPK11 | |
| SCHEMBL6167100 | 0.87 | RAF1 (0.57) | MAPK14MAPK12RAF1MAPK13MAPK11 | |
| SCHEMBL6164609 | 0.86 | MAPK14 (0.53) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL7829896 | 0.86 | RAF1 (0.52) | MAPK14MAPK12RAF1MAPK13MAPK11 | |
| SCHEMBL6162559 | 0.83 | MAPK14 (0.61) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6162310 | 0.83 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6162134 | 0.82 | MAPK14 (0.52) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6162634 | 0.81 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6164566 | 0.80 | RAF1 (0.52) | MAPK14MAPK12HCKTNFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |