Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.58 |
| ▸ | HCK | P08631 | 9/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163672 | 0.96 | MAPK14 (0.53) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL7665705 | 0.91 | MAPK14 (0.50) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6165244 | 0.88 | MAPK14 (0.50) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6163825 | 0.87 | MAPK14 (0.51) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6163413 | 0.85 | MAPK14 (0.53) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6163294 | 0.83 | MAPK14 (0.61) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6164616 | 0.83 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6162634 | 0.81 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6163300 | 0.80 | MAPK14 (0.49) | MAPK14MAPK12HCKTNFRAF1 | |
| SCHEMBL6167223 | 0.80 | MAPK14 (0.68) | MAPK14MAPK12HCKTNFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |