Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167495 | 0.92 | GRM2 (0.45) | GRM2CYP3A4GRM3 | |
| SCHEMBL6164115 | 0.91 | GRM2 (0.45) | GRM2CYP3A4GRM3 | |
| SCHEMBL6165964 | 0.89 | GRM2 (0.44) | GRM2CYP3A4GRM3 | |
| SCHEMBL6168533 | 0.88 | GRM2 (0.48) | GRM2CYP3A4GRM3 | |
| SCHEMBL6165041 | 0.88 | GRM2 (0.46) | GRM2CYP3A4GRM3 | |
| SCHEMBL6167278 | 0.84 | CYP3A4 (0.42) | GRM2CYP3A4GRM3 | |
| SCHEMBL6162628 | 0.78 | CYP3A4 (0.52) | GRM2CYP3A4GRM3 | |
| SCHEMBL6166716 | 0.78 | GRM2 (0.44) | GRM2CYP3A4GRM3 | |
| SCHEMBL6165782 | 0.77 | GRM2 (0.49) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557053 | 0.77 | GRM2 (0.59) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | claimed |