Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163335 | 0.89 | GRM2 (0.47) | GRM2CYP3A4GRM3 | |
| SCHEMBL6164544 | 0.89 | GRM2 (0.47) | GRM2CYP3A4GRM3 | |
| SCHEMBL6165782 | 0.89 | GRM2 (0.49) | GRM2CYP3A4GRM3 | |
| SCHEMBL6166445 | 0.86 | GRM2 (0.51) | GRM2CYP3A4GRM3 | |
| SCHEMBL6164053 | 0.85 | GRM2 (0.49) | GRM2CYP3A4GRM3 | |
| SCHEMBL6166940 | 0.82 | CYP3A4 (0.42) | GRM2CYP3A4GRM3 | |
| SCHEMBL6164871 | 0.79 | GRM2 (0.49) | GRM2CYP3A4GRM3 | |
| SCHEMBL6164581 | 0.79 | GRM2 (0.52) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557071 | 0.78 | GRM2 (0.57) | GRM2CYP3A4 | |
| SCHEMBL6164951 | 0.78 | GRM2 (0.44) | GRM2CYP3A4GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | claimed |