Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | NISCH | Q9Y2I1 | 7/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160956 | 0.85 | NISCH (0.56) | NISCHPPARGHTR1DADRA1A | |
| SCHEMBL6165524 | 0.81 | NISCH (0.45) | ALDH1A1RECQLNISCHPPARGHTR1D | |
| SCHEMBL5496699 | 0.77 | ALDH1A1 (0.74) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL11124323 | 0.77 | ALDH1A1 (0.78) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL1494452 | 0.76 | ALDH1A1 (0.72) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL9556731 | 0.76 | ALDH1A1 (0.76) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL6782409 | 0.76 | ALDH1A1 (0.76) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL7779924 | 0.75 | ALDH1A1 (0.71) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL9849155 | 0.75 | ALDH1A1 (0.74) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL9556830 | 0.75 | ALDH1A1 (0.74) | ALDH1A1RECQLPKMKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| CN-1142492-A | Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |