SCHEMBL6165629

SCHEMBL6165629

[c]1nc(Cc2ccncc2)co1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 8/20 0.37
CYP11B1 P15538 8/20 0.37
CYP11B2 P19099 8/20 0.37
CYP19A1 P11511 5/20 0.37
CYP3A4 P08684 5/20 0.36
LOXL2 Q9Y4K0 2/20 0.35
HRH4 Q9H3N8 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
POLB P06746 1/20 0.34
S1PR1 P21453 2/20 0.33
S1PR3 Q99500 1/20 0.33
HDAC1 Q13547 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1830984 0.82 CALM1 (0.42) ALDH1A1SMN1; SMN2POLB
SCHEMBL6166150 0.79 HRH4 (0.42) CYP11B1CYP11B2HRH4HRH3CYP1A2
SCHEMBL2224268 0.69 CYP17A1 (0.44) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL721736 0.68 CYP17A1 (0.61) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL13873567 0.66 CYP17A1 (0.65) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL6163991 0.65 CYP17A1 (0.40) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL6165757 0.65 HRH4 (0.39) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL27627421 0.64 CYP17A1 (0.38) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL14257671 0.62 CYP17A1 (0.54) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4
SCHEMBL19412904 0.61 POLB (0.38) CYP17A1CYP11B1CYP11B2CYP19A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417177-A4 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL MYERS SQUIBB PHARMA CO (US) 2005-10-19 EP disclosed
EP-1417177-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003007883-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-01-30 WO disclosed
EP-1071668-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Du Pont Pharmaceuticals Company (US) 2001-01-31 EP disclosed
WO-1999054308-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS DU PONT PHARMACEUTICALS COMPANY (US) 1999-10-28 WO disclosed