Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249071 | 0.80 | GAA (0.49) | PTGS2NPSR1TDP1POLBGAA | |
| SCHEMBL21634257 | 0.71 | HDAC6 (1.00) | HDAC6GRIN2BPTGS2 | |
| SCHEMBL6166241 | 0.71 | POLB (0.40) | GRIN2BPOLBKDM4E | |
| SCHEMBL4246332 | 0.70 | POLB (0.47) | POLBGAAHSD17B10KDM4E | |
| SCHEMBL12605547 | 0.69 | GRIN2B (0.57) | GRIN2BPTGS2NPSR1TDP1POLB | |
| SCHEMBL28227305 | 0.69 | MAPT (0.59) | TDP1POLBSMN1; SMN2KDM4EFKBP1A | |
| SCHEMBL30622457 | 0.69 | GRIN2B (0.55) | HDAC6GRIN2BPTGS2 | |
| SCHEMBL20605099 | 0.69 | GRIN2B (0.55) | HDAC6GRIN2BPTGS2 | |
| SCHEMBL20604745 | 0.68 | KMT2A (0.56) | GRIN2B | |
| SCHEMBL12605579 | 0.68 | GRIN2B (0.62) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | claimed |
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | disclosed |