Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246332 | 0.83 | POLB (0.47) | POLBKDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL13522478 | 0.80 | POLB (0.44) | POLBKDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL6165302 | 0.79 | GRIN2B (0.44) | GRIN2BMCHR1 | |
| SCHEMBL841380 | 0.77 | HCAR3 (0.46) | POLBKDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL13522483 | 0.76 | KDM4E (0.47) | PLA2G4AKDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL20592531 | 0.76 | HDAC6 (0.52) | POLBPLA2G4AMCHR1ALDH1A1MEN1 | |
| SCHEMBL1014690 | 0.75 | B3GNT2 (0.47) | POLBKDM5AKDM4CKDM5BGRIN2B | |
| SCHEMBL4250812 | 0.74 | HCAR3 (0.49) | POLBALDH1A1RAB9AKMT2AHCAR3 | |
| SCHEMBL13522487 | 0.73 | ALDH1A1 (0.37) | POLBKDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL2583269 | 0.73 | ALDH1A1 (0.54) | KDM5AKDM4CKDM5BALDH1A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100346792-C | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | claimed |
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| CN-1589146-A | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2005-03-02 | — | — | CN | claimed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | claimed |
| CN-100346792-C | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | disclosed |
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| CN-1589146-A | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2005-03-02 | — | — | CN | disclosed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | disclosed |