Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162254 | 0.91 | FBP1 (0.60) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL6163188 | 0.91 | FBP1 (0.60) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4225644 | 0.88 | FBP1 (0.63) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4231406 | 0.88 | FBP1 (0.63) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4230355 | 0.86 | FBP1 (0.60) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4230181 | 0.86 | FBP1 (0.60) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4226538 | 0.84 | KDR (0.64) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4226644 | 0.84 | KDR (0.64) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4222199 | 0.81 | KDR (0.61) | FBP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4230216 | 0.81 | KDR (0.61) | FBP1KDRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163227-B1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-28 | — | — | EP | disclosed |