Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.55 |
| ▸ | AKT2 | P31751 | 2/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.55 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162786 | 1.00 | AKT1 (0.55) | AKT1AKT2AKT3CYP51A1HDAC8 | |
| Hydrochloric Acid SCHEMBL25268077 | 0.99 | AKT1 (0.54) | AKT1AKT2AKT3CYP51A1HDAC8 | |
| Hydrochloric Acid SCHEMBL25221908 | 0.99 | AKT1 (0.54) | AKT1AKT2AKT3CYP51A1HDAC8 | |
| SCHEMBL19576823 | 0.85 | AKT1 (0.58) | AKT1AKT2AKT3HDAC8HDAC3 | |
| SCHEMBL6052885 | 0.84 | NLN (0.59) | CYP51A1DPP7NLNOPRD1 | |
| SCHEMBL6165188 | 0.84 | NLN (0.59) | CYP51A1DPP7NLNOPRD1 | |
| Hydrochloric Acid SCHEMBL6163223 | 0.83 | NLN (0.58) | CYP51A1HDAC8DPP7NLNOPRD1 | |
| Hydrochloric Acid SCHEMBL6163217 | 0.83 | NLN (0.58) | CYP51A1HDAC8DPP7NLNOPRD1 | |
| SCHEMBL3133533 | 0.81 | OPRD1 (0.65) | AKT1AKT2AKT3HDAC8DPP7 | |
| SCHEMBL6161830 | 0.81 | OPRD1 (0.65) | AKT1AKT2AKT3HDAC8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107597-A2 | BICYCLIC HETEROAROMATIC AMIDE COMPOUNDS AND USES THEREOF | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |