Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 4/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164246 | 1.00 | MAPT (0.46) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6161520 | 0.93 | SMN1; SMN2 (0.53) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6163317 | 0.89 | MAPT (0.56) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6162430 | 0.88 | SMN1; SMN2 (0.60) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6166657 | 0.88 | MAPT (0.44) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6163170 | 0.86 | SMN1; SMN2 (0.52) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6165503 | 0.85 | SNCA (0.44) | MAPTMAPK1SMN1; SMN2LMNARAB9A | |
| SCHEMBL6162773 | 0.85 | MAPT (0.48) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6165221 | 0.85 | MAPT (0.48) | MAPTMAPK1SMN1; SMN2NPC1LMNA | |
| SCHEMBL6203639 | 0.85 | CACNA1F (0.43) | MAPTMAPK1SMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254136-A4 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD (KR) | 2005-06-01 | — | — | EP | disclosed |
| EP-1254136-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG Chem Investment, Ltd. (KR) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055146-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD. (KR) | 2001-08-02 | — | — | WO | disclosed |