Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163103 | 1.00 | DHODH (0.56) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6163110 | 1.00 | DHODH (0.56) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6162326 | 0.95 | DHODH (0.51) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6162262 | 0.95 | DHODH (0.51) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6164238 | 0.95 | DHODH (0.51) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6161778 | 0.91 | KDM4E (0.59) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6161828 | 0.91 | KDM4E (0.59) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6163206 | 0.91 | KDM4E (0.59) | DHODHHCRTR1HCRTR2TRPV1KDM4E | |
| SCHEMBL6161963 | 0.89 | TRPV1 (0.57) | TRPV1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6163232 | 0.89 | TRPV1 (0.57) | TRPV1KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337523-B1 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORP (US) | 2005-10-19 | — | — | EP | claimed |
| US-20040048867-A1 | 2,4-Substituted pyridine derivatives | NEUROGEN CORPORATION | 2004-03-11 | — | — | US | claimed |
| EP-1337523-A2 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2003-08-27 | — | — | EP | claimed |
| US-6559163-B2 | Agonists, antagonists or inverse agonists for GABAA brain receptors; useful in diagnosis and treatment of anxiety, depression | NEUROGEN CORPORATION | 2003-05-06 | — | — | US | claimed |
| US-20020161008-A1 | 2,4-Substituted pyridine derivatives | NEUROGEN CORPORATION | 2002-10-31 | — | — | US | claimed |
| WO-2002014269-A2 | 2,4-SUBSTITUTED PYRIDINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2002-02-21 | — | — | WO | claimed |
| US-6559163-B2 | Agonists, antagonists or inverse agonists for GABAA brain receptors; useful in diagnosis and treatment of anxiety, depression | NEUROGEN CORPORATION | 2003-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161008-A1 | 2,4-Substituted pyridine derivatives | GABARAP, GABRB1, GABARAPL1 | DHODH 2235/4885HCRTR1 81/4885HCRTR2 88/4885 |
| US-20040048867-A1 | 2,4-Substituted pyridine derivatives | GABARAP, GABRB1, GABARAPL1 | DHODH 2235/4885HCRTR1 81/4885HCRTR2 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.