Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17800950 | 0.93 | POLB (0.57) | POLBTSHRHTTGAAKMT2A | |
| SCHEMBL25060205 | 0.93 | POLB (0.57) | POLBTSHRHTTGAAKMT2A | |
| SCHEMBL16431557 | 0.85 | ALPI (0.45) | POLBALPIPKMPTGS1XIAP | |
| SCHEMBL630660 | 0.83 | TSHR (0.57) | POLBTSHRHTTKMT2AEZH2 | |
| SCHEMBL631684 | 0.80 | POLB (0.51) | POLBTSHRHTTKMT2AEZH2 | |
| SCHEMBL25060405 | 0.80 | POLB (0.46) | POLBTSHRHTTGAAKMT2A | |
| SCHEMBL14417240 | 0.79 | ALPI (0.50) | KDM4EALPIPKMPTGS1XIAP | |
| SCHEMBL6166506 | 0.78 | TDP1 (0.61) | KDM4EALPIPKMPTGS1XIAP | |
| SCHEMBL3006748 | 0.77 | XIAP (0.51) | TSHRGAAKDM4EALPIPKM | |
| SCHEMBL353959 | 0.77 | TDP1 (0.64) | TSHRKDM4EALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |