Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164081 | 1.00 | TDP1 (0.64) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7759004 | 0.99 | TDP1 (0.62) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6166506 | 0.98 | TDP1 (0.61) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20474616 | 0.90 | ALDH1A1 (0.62) | TDP1ALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL18553983 | 0.90 | ALDH1A1 (0.62) | TDP1ALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| Trifluoromethanesulfonic Acid SCHEMBL8424410 | 0.89 | TDP1 (0.53) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3006742 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3006748 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3006751 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL14417240 | 0.87 | ALPI (0.50) | TDP1ALDH1A1KDM4ESMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-8835654-B2 | Method and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-09-16 | — | — | US | disclosed |
| US-20140107027-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | BHI LIMITED PARTNERSHIP (CA) | 2014-04-17 | — | — | US | disclosed |
| US-8642801-B2 | Methods and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-02-04 | — | — | US | disclosed |
| CN-101157720-B | Template-fixed peptidomimetics as serine protease inhibitors | POLYPHOR LTD | 2012-04-04 | — | — | CN | disclosed |
| US-20120015911-A1 | METHOD AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | BELLUS HEALTH INC. (CA) | 2012-01-19 | — | — | US | disclosed |
| US-8044100-B2 | Methods and compositions for treating amyloid-related diseases | BELLUS HEALTH INC. (CA) | 2011-10-25 | — | — | US | disclosed |
| US-20100113591-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2010-05-06 | — | — | US | disclosed |
| CN-1688600-B | Template-fixed peptidomimetics with antibacterial activity | POLYPHOR LTD | 2010-04-28 | — | — | CN | disclosed |
| US-20100056432-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY | POLYPHOR LTD. (CH) | 2010-03-04 | — | — | US | disclosed |
| WO-2004083199-A1 | SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2004-09-30 | — | — | WO | disclosed |
| EP-1458747-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF SERINE PROTEASES | Polyphor Ltd. (CH) | 2004-09-22 | — | — | EP | disclosed |
| US-20040171066-A1 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2004-09-02 | — | — | US | disclosed |
| WO-2004018503-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY | POLYPHOR LTD. (CH) | 2004-03-04 | — | — | WO | disclosed |
| WO-2003054000-A1 | TEMPLATE-FIXED PEPTIDOMIMETICSAS INHIBITORS OF SERINE PROTEASES | POLYPHOR LTD. (CH) | 2003-07-03 | — | — | WO | disclosed |
| EP-0640618-B1 | Tetrahydronaphthalene-peptide derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-20 | — | — | EP | disclosed |
| US-5837807-A | DIPEPTIDES AND CYCLIC PEPTIDE DERIVATIVES OF AMINO TETRAHYDRONAPHTHALENECARBOXYLIC ACID AND HELICAL DOMAINS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | disclosed |
| US-5644024-A | MIMICS OF PEPTIDE DOMAINS, SEQUENCE DETERMINATION, DRUGS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0729972-A1 | Peptide derivatives of tetrahydronaphthalene | F. HOFFMANN-LA ROCHE AG (CH) | 1996-09-04 | — | — | EP | disclosed |
| EP-0640618-A1 | Tetrahydronaphthalene-peptide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | TDP1 650/4885EPHX2 678/4885ALDH1A1 2989/4885 |
| US-20140107027-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | TDP1 650/4885EPHX2 678/4885ALDH1A1 2989/4885 |
| US-20040171066-A1 | Template-fixed peptidomimetics with antimicrobial activity | ZFR, POLR1C, ZC3HAV1 | TDP1 3143/4885EPHX2 4714/4885ALDH1A1 2186/4885 |
| US-20100056432-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY | POLL, QPCTL, PEPD | TDP1 3797/4885EPHX2 4821/4885ALDH1A1 1705/4885 |
| US-20100113591-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | TDP1 650/4885EPHX2 678/4885ALDH1A1 2989/4885 |
| US-20120015911-A1 | METHOD AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | TDP1 793/4885EPHX2 660/4885ALDH1A1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.