Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166939 | 0.91 | PDE4B (0.52) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL4707984 | 0.88 | PDE4B (0.55) | PDE4BACHEBACE1ALDH1A1HSD17B10 | |
| SCHEMBL4706104 | 0.88 | PDE4B (0.68) | PDE4B | |
| SCHEMBL4708376 | 0.87 | PDE4B (0.66) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL4708156 | 0.87 | PDE4B (0.59) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL4706044 | 0.86 | PDE4B (0.55) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL4707585 | 0.85 | PDE4B (0.55) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL6169793 | 0.84 | PDE4B (0.56) | PDE4BACHEBACE1ALDH1A1POLB | |
| SCHEMBL4706435 | 0.83 | PDE4B (0.79) | PDE4BTP53 | |
| SCHEMBL4705746 | 0.83 | PDE4B (0.72) | PDE4BACHEBACE1TP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |