Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166936 | 0.91 | PDE4B (0.58) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4707984 | 0.86 | PDE4B (0.55) | PDE4BACHEBACE1ALDH1A1MEN1 | |
| SCHEMBL4708376 | 0.86 | PDE4B (0.66) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4706044 | 0.84 | PDE4B (0.55) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4707585 | 0.83 | PDE4B (0.55) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4706104 | 0.81 | PDE4B (0.68) | PDE4B | |
| SCHEMBL4705746 | 0.81 | PDE4B (0.72) | PDE4BACHEBACE1TP53MAPT | |
| SCHEMBL6169793 | 0.80 | PDE4B (0.56) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4708156 | 0.80 | PDE4B (0.59) | PDE4BACHEBACE1POLBALDH1A1 | |
| SCHEMBL4706107 | 0.80 | PDE4B (0.70) | PDE4BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |