Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166406 | 0.90 | CCNA2 (0.41) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166604 | 0.87 | CCNA2 (0.39) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6162683 | 0.86 | CCNA2 (0.38) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166539 | 0.86 | SRC (0.39) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6164575 | 0.84 | CCNA2 (0.38) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6167233 | 0.83 | CDK2 (0.39) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6164065 | 0.82 | SMN1; SMN2 (0.44) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6167448 | 0.81 | CYP1A2 (0.39) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6163631 | 0.81 | CCNA2 (0.39) | KDM4ECCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6185430 | 0.80 | CCNA2 (0.43) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |