Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167448 | 0.85 | CYP1A2 (0.39) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6163693 | 0.84 | RAB9A (0.41) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6164787 | 0.79 | CCNA2 (0.39) | CDK2CCNA2RAB9ASMN1; SMN2 | |
| SCHEMBL6164575 | 0.75 | CCNA2 (0.38) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6166604 | 0.73 | CCNA2 (0.39) | CDK2CCNA2RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6164821 | 0.69 | CYP1A2 (0.43) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6167555 | 0.63 | CCNA2 (0.39) | CDK2CCNA2RAB9ASMN1; SMN2 | |
| SCHEMBL6166839 | 0.63 | ALDH1A1 (0.50) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6166942 | 0.62 | HTT (0.43) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6164846 | 0.61 | CCNA2 (0.38) | CDK2CCNA2RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |