Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 11/20 | 0.35 |
| ▸ | ACHE | P22303 | 11/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509166 | 0.88 | CCNT1 (0.36) | BCHEACHEC5AR1CCNT1CDK9 | |
| SCHEMBL72861 | 0.88 | C5AR1 (0.38) | BCHEACHEC5AR1HTTSMN1; SMN2 | |
| SCHEMBL61126 | 0.86 | BCHE (0.35) | BCHEACHEC5AR1CCNT1CDK9 | |
| SCHEMBL73579 | 0.85 | CCNT1 (0.36) | BCHEACHEC5AR1CCNT1CDK9 | |
| SCHEMBL61151 | 0.85 | PDK4 (0.40) | BCHEACHE | |
| SCHEMBL62101 | 0.81 | C5AR1 (0.35) | BCHEACHEC5AR1CCNT1CDK9 | |
| SCHEMBL62344 | 0.79 | ACHE (0.43) | BCHEACHEC5AR1HTTSMN1; SMN2 | |
| SCHEMBL3818877 | 0.78 | ACHE (0.34) | BCHEACHEC5AR1HTTSMN1; SMN2 | |
| SCHEMBL61659 | 0.77 | C5AR1 (0.37) | BCHEACHEC5AR1MEN1KMT2A | |
| SCHEMBL13949214 | 0.76 | BCHE (0.39) | BCHEACHEMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129395-B2 | 4,5-disubstituted-2-aryl pyrimidines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-03-06 | — | — | US | disclosed |