Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22341281 | 0.70 | KEAP1 (0.38) | KEAP1NFE2L2EPHX1CHRM3SSTR4 | |
| SCHEMBL27470523 | 0.70 | CA12 (0.31) | EPHX1SSTR4 | |
| SCHEMBL1046906 | 0.70 | SSTR4 (0.33) | EPHX1SSTR4 | |
| SCHEMBL5949599 | 0.69 | KEAP1 (0.30) | KEAP1NFE2L2 | |
| SCHEMBL11814849 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2EPHX1CHRM3SSTR4 | |
| SCHEMBL6255794 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2EPHX1CHRM3SSTR4 | |
| SCHEMBL4728809 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2EPHX1CHRM3SSTR4 | |
| SCHEMBL7871768 | 0.68 | EPHX1 (0.37) | KEAP1NFE2L2EPHX1CHRM3SSTR4 | |
| SCHEMBL29004544 | 0.67 | EPHX1 (0.44) | EPHX1SSTR4 | |
| SCHEMBL1876976 | 0.67 | EPHX1 (0.39) | KEAP1NFE2L2EPHX1CHRM3SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534281-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | Astrazeneca AB (SE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004006925-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |