SCHEMBL6167820

SCHEMBL6167820

CCCCC(=O)N1CCCC1c1nnc(-c2cccc(Cl)c2)o1.O=C(CCC1CCCC1)N1CCCC1c1nnc(-c2cccc(Cl)c2)o1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 8/20 0.54
HCRTR2 O43614 7/20 0.54
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
TSHR P16473 1/20 0.49
TP53 P04637 1/20 0.49
F2 P00734 1/20 0.45
TNKS O95271 1/20 0.43
PARP1 P09874 1/20 0.43
PARP2 Q9UGN5 1/20 0.43
POLB P06746 1/20 0.42
GRM5 P41594 4/20 0.42
USP30 Q70CQ3 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3367060 0.94 HCRTR1 (0.59) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL3367281 0.94 HCRTR1 (0.57) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL3370192 0.83 HCRTR1 (0.52) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL3366754 0.82 HCRTR1 (0.60) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL13114280 0.78 POLB (0.61) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL3369975 0.77 HSD11B1 (0.52) HCRTR1HCRTR2SMN1; SMN2ALDH1A1LMNA
SCHEMBL3367532 0.76 HCRTR1 (0.47) HCRTR1HCRTR2ALDH1A1LMNATSHR
SCHEMBL3366658 0.73 HCRTR1 (0.59) HCRTR1HCRTR2ALDH1A1LMNATSHR
SCHEMBL3365251 0.72 HCRTR1 (0.48) HCRTR1HCRTR2ALDH1A1TNKSPARP1
SCHEMBL5332089 0.71 GRM5 (0.72) HCRTR1HCRTR2GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532141-A1 2-PYRROLIDIN-2-YL- 1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS Grünenthal GmbH (DE) 2005-05-25 EP claimed
WO-2004024725-A1 2-PYRROLIDIN-2-YL-[1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS Grünenthal GmbH (DE) 2004-03-25 WO claimed