Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382531 | 0.98 | EPHX2 (0.56) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL3236215 | 0.98 | EPHX2 (0.52) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| SCHEMBL2079376 | 0.95 | TSHR (0.50) | EPHX2TSHRL3MBTL1TDP1SPHK1 | |
| SCHEMBL906396 | 0.89 | TSHR (0.52) | TSHRL3MBTL1TDP1LMNAHTT | |
| SCHEMBL27375020 | 0.88 | TSHR (0.47) | EPHX2TSHRL3MBTL1TDP1SPHK1 | |
| SCHEMBL712393 | 0.87 | MAPT (0.56) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| SCHEMBL25269510 | 0.86 | EPHX2 (0.57) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| SCHEMBL1007119 | 0.86 | MAPT (0.59) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| SCHEMBL830483 | 0.86 | MAPT (0.59) | EPHX2TSHRFAAHL3MBTL1TDP1 | |
| SCHEMBL2867823 | 0.86 | MAPT (0.59) | EPHX2TSHRFAAHL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | disclosed |