Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.70 |
| ▸ | MAOA | P21397 | 9/20 | 0.70 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.63 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168060 | 1.00 | MAOB (0.70) | MAOBMAOAS1PR1S1PR5PDGFRA | |
| SCHEMBL6169219 | 0.89 | MAOB (0.77) | MAOBMAOAS1PR1S1PR5PDGFRA | |
| SCHEMBL6169229 | 0.89 | MAOB (0.77) | MAOBMAOAS1PR1S1PR5PDGFRA | |
| SCHEMBL21348014 | 0.88 | MAOB (0.89) | MAOBMAOASPHK1SCN3A | |
| SCHEMBL6170997 | 0.88 | MAOB (0.73) | MAOBMAOAS1PR1S1PR5SPHK1 | |
| SCHEMBL6170993 | 0.88 | MAOB (0.73) | MAOBMAOAS1PR1S1PR5SPHK1 | |
| SCHEMBL29288198 | 0.83 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL29288195 | 0.83 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL7314623 | 0.81 | ALDH1A1 (0.66) | MAOBMAOASPHK1SCN3ASCN9A | |
| SCHEMBL28107109 | 0.81 | ALDH1A1 (0.66) | MAOBMAOASPHK1SCN3ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1524265-A1 | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors | Newron Pharmaceuticals S.p.A. (IT) | 2005-04-20 | — | — | EP | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |
| EP-1524265-A1 | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors | Newron Pharmaceuticals S.p.A. (IT) | 2005-04-20 | — | — | EP | disclosed |