Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166416 | 0.84 | CHRM3 (0.52) | HTR2CKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5103372 | 0.84 | SLC18A3 (0.40) | HTR2CKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6168628 | 0.83 | CHRM3 (0.52) | KMT2AMEN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8571208 | 0.82 | KDM1A (0.40) | HTR2CKMT2AMEN1ALDH1A1 | |
| SCHEMBL6169679 | 0.79 | CHRM3 (0.48) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL8565700 | 0.79 | CHRM3 (0.56) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL8570359 | 0.78 | CHRM3 (0.51) | DDB1CRBNKMT2AMEN1KDM4E | |
| SCHEMBL6167647 | 0.78 | SLC6A2 (0.38) | HTR2CKMT2AMEN1HTR7ALDH1A1 | |
| SCHEMBL8567234 | 0.77 | CHRM2 (0.50) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL8568450 | 0.77 | KDM1A (0.38) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122253-B1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6645971-B1 | Pollakiuria and urinary incontinence treatment; muscarinic receptor antagonists; anticholinergic, anticonvulsants, antiulcer, and antiasthmatics; Parkinson*s disease | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2003-11-11 | — | — | US | disclosed |
| EP-1122253-A1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-08-08 | — | — | EP | disclosed |