Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411631 | 0.84 | TGFBR1 (0.46) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6168732 | 0.81 | KMT2A (0.51) | ALDH1A1MAPT | |
| SCHEMBL6169745 | 0.80 | TGFBR1 (0.43) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6168797 | 0.77 | TGFBR1 (0.41) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6169733 | 0.75 | PDE3B (0.48) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6167362 | 0.75 | TGFBR1 (0.39) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6760985 | 0.74 | TGFBR1 (0.70) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6169245 | 0.73 | PDE3B (0.46) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL27756008 | 0.72 | TGFBR1 (0.56) | TGFBR1MAPK14ALDH1A1MTOR | |
| SCHEMBL6169255 | 0.71 | HTT (0.48) | TGFBR1MAPK14RIPK2ACVR1BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050165011-A1 | Benzoxazine and benzoxazinone substituted triazoles | GELLIBERT FRANCOISE J (FR) | 2005-07-28 | — | — | US | disclosed |
| EP-1506191-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097639-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165011-A1 | Benzoxazine and benzoxazinone substituted triazoles | ACVR1, TGFBR1, SMAD3 | TGFBR1 2/4885MAPK14 105/4885RIPK2 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.