Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | RHEB | Q15382 | 7/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168641 | 0.83 | FLT3 (0.60) | GRIN1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8499338 | 0.82 | MEN1 (0.71) | GRIN1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29531428 | 0.80 | GRIN1 (1.00) | GRIN1MEN1KMT2ARHEBALOX15 | |
| SCHEMBL727389 | 0.80 | GRIN1 (1.00) | GRIN1MEN1KMT2ARHEBALOX15 | |
| SCHEMBL6168680 | 0.79 | MEN1 (0.58) | MEN1KMT2ANPC1RAB9ARHEB | |
| SCHEMBL3033007 | 0.77 | GRIN1 (0.74) | GRIN1MEN1KMT2ARHEBALOX15 | |
| SCHEMBL6170605 | 0.77 | MEN1 (0.78) | MEN1KMT2ANPC1RAB9AALOX15 | |
| SCHEMBL22529402 | 0.76 | GRIN1 (0.72) | GRIN1MEN1KMT2ARHEBALOX15 | |
| SCHEMBL20505089 | 0.76 | GRIN1 (0.72) | GRIN1MEN1KMT2ARHEBALOX15 | |
| SCHEMBL6170489 | 0.75 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |