Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168641 | 0.83 | FLT3 (0.60) | MEN1KMT2ANPC1RAB9AHRH4 | |
| SCHEMBL708527 | 0.82 | GRIN1 (0.57) | MEN1KMT2AHRH4ALOX15CYP1A2 | |
| SCHEMBL6168465 | 0.79 | GRIN1 (0.67) | MEN1KMT2ANPC1RAB9AALOX15 | |
| SCHEMBL12428146 | 0.77 | HSD17B10 (0.74) | MEN1KMT2ANPC1RAB9AHTR6 | |
| SCHEMBL6170489 | 0.75 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9AALOX15 | |
| SCHEMBL24754486 | 0.74 | HRH4 (0.56) | KMT2ANPC1HRH4ALOX15FLT3 | |
| SCHEMBL19331400 | 0.74 | HRH4 (0.56) | NPC1RAB9AHRH4CYP1A2FLT3 | |
| SCHEMBL30039640 | 0.74 | HRH4 (0.56) | NPC1RAB9AHRH4CYP1A2FLT3 | |
| SCHEMBL11002795 | 0.74 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9AALOX15 | |
| SCHEMBL29399564 | 0.71 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |