Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708464 | 0.97 | PDE4B (0.55) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4708156 | 0.95 | PDE4B (0.59) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4708376 | 0.89 | PDE4B (0.66) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4708499 | 0.84 | PDE4B (0.51) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL6166936 | 0.83 | PDE4B (0.58) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL1652093 | 0.82 | PDE4B (0.56) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4707585 | 0.81 | PDE4B (0.55) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706135 | 0.81 | PDE4B (0.62) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706084 | 0.81 | PDE4B (0.62) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL6169793 | 0.81 | PDE4B (0.56) | PDE4BACHEBACE1PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | claimed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | claimed |