Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171740 | 0.96 | OPRD1 (0.75) | OPRD1OPRK1OPRM1DRD3 | |
| SCHEMBL6602593 | 0.89 | OPRD1 (1.00) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6171286 | 0.88 | OPRD1 (0.74) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6171425 | 0.88 | OPRD1 (0.76) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6169296 | 0.88 | OPRD1 (0.74) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6172905 | 0.87 | OPRD1 (1.00) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7665640 | 0.86 | OPRD1 (0.75) | OPRD1OPRK1OPRM1DRD3 | |
| SCHEMBL6171494 | 0.86 | OPRD1 (0.82) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6169458 | 0.85 | OPRD1 (0.60) | OPRD1OPRK1OPRM1DRD3 | |
| SCHEMBL6171181 | 0.85 | OPRD1 (0.82) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112255-B1 | 4,4-BIARYLPIPERIDINE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | PFIZER PROD INC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040138220-A1 | 4,4-Biarylpiperidine derivatives | PFIZER, INC. | 2004-07-15 | — | — | US | disclosed |
| US-6720336-B2 | USED AS LIGANDS FOR OPIOID RECEPTORS, FOR THERAPY OF NEUROLOGICAL AND GASTROINTESTINAL DISORDERS | PFIZER, INC. | 2004-04-13 | — | — | US | disclosed |
| US-20020013321-A1 | 4,4-Biarylpiperidine derivatives | PFIZER INC. | 2002-01-31 | — | — | US | disclosed |
| EP-1112255-A1 | 4,4-BIARYLPIPERIDINE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000014066-A1 | 4,4-BIARYLPIPERIDINE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2000-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138220-A1 | 4,4-Biarylpiperidine derivatives | CYP4B1, CYP3A5, CYP3A4 | OPRD1 50/4885OPRK1 159/4885OPRM1 166/4885 |
| US-20020013321-A1 | 4,4-Biarylpiperidine derivatives | CYP4B1, CYP3A5, CYP3A4 | OPRD1 50/4885OPRK1 159/4885OPRM1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.