⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168638 | 1.00 | — | — | |
| SCHEMBL28352138 | 0.97 | ALDH1A1 (0.38) | — | |
| SCHEMBL13711309 | 0.79 | — | — | |
| SCHEMBL8385948 | 0.79 | — | — | |
| SCHEMBL4903558 | 0.79 | — | — | |
| SCHEMBL7030376 | 0.77 | — | — | |
| SCHEMBL7030375 | 0.77 | — | — | |
| SCHEMBL9846205 | 0.74 | — | — | |
| SCHEMBL9846201 | 0.74 | — | — | |
| SCHEMBL17857686 | 0.74 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032662-B | Compounds that interact with the RAS superfamily for the treatment of cancer, inflammatory diseases, RAS proteinopathies and fibrotic diseases | 尚医治疗有限责任公司 | 2024-10-15 | — | — | CN | disclosed |
| EP-4331679-A2 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | Shy Therapeutics LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| US-20230149369-A1 | Compounds that Interact with the Ras Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease | SHY Therapeutics LLC (US) | 2023-05-18 | — | — | US | disclosed |
| US-11541041-B1 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2023-01-03 | — | — | US | disclosed |
| US-20220347162-A1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, INC. | 2022-11-03 | — | — | US | disclosed |
| US-11213515-B1 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2022-01-04 | — | — | US | disclosed |
| US-11026930-B1 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2021-06-08 | — | — | US | disclosed |
| US-11000515-B2 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2021-05-11 | — | — | US | disclosed |
| US-10940139-B2 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2021-03-09 | — | — | US | disclosed |
| WO-2018237084-A1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2018-12-27 | — | — | WO | disclosed |
| US-20050202973-A1 | Aryl-alkyne compounds as herbicides | SYNGENTA CROP PROTECTION, INC. | 2005-09-15 | — | — | US | disclosed |
| EP-1507768-A1 | ARYL-ALKYNE COMPOUNDS AS HERBICIDES | Syngenta Participations AG (CH) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003087067-A1 | ARYL-ALKYNE COMPOUNDS AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-10-23 | — | — | WO | disclosed |
| US-6620932-B2 | 2-alkoxy group may be introduced into the appropriate pyrimidine derivatives at the start of the reaction | DEGUSSA AG (DE) | 2003-09-16 | — | — | US | disclosed |
| US-20030022908-A1 | 2-alkoxy-5-methoxypyrimidines or their tautomeric forms and methods for producing the same | DEGUSSA AG (DE) | 2003-01-30 | — | — | US | disclosed |
| US-5055221-A | Rapidly switching ferroelectric display element | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-10-08 | — | — | US | disclosed |
| US-4760169-A | Process for the preparation of hydroxymethylenealkoxyacetic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1988-07-26 | — | — | US | disclosed |
| US-4665218-A | Method for the preparation of alkoxymethylene compounds of acetic esters and substituted acetic esters | DYNAMIT NOBEL AG (DE) | 1987-05-12 | — | — | US | disclosed |
| US-4536574-A | REACTING SULFONYLOXYACETONITRILE WITH ALCOHOL, AMMONIUM CHLORIDE, ALKALI METAL THIOLATE AND KETOCARBOXYLIC ESTER | BAYER AKTIENGESELLSCHAFT (DE) | 1985-08-20 | — | — | US | disclosed |