Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 4/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515036 | 1.00 | KCNH2 (0.57) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL6167085 | 0.91 | KCNH2 (0.67) | KCNH2ALDH1A1POLBOPRM1CYP3A4 | |
| SCHEMBL6166236 | 0.91 | KCNH2 (0.67) | KCNH2ALDH1A1POLBOPRM1CYP3A4 | |
| SCHEMBL2080667 | 0.86 | CYP3A4 (0.64) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL2080669 | 0.86 | CYP3A4 (0.64) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL27494276 | 0.85 | KCNH2 (0.46) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL6165834 | 0.85 | KCNH2 (0.46) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL7468329 | 0.85 | KCNH2 (0.55) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL7468336 | 0.85 | KCNH2 (0.55) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4726916 | 0.84 | CYP3A4 (0.60) | KCNH2ALDH1A1POLBOPRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134219-B1 | CYCLOALKYL-SUBSTITUTED AMINOMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-6573260-B1 | Antibiotics | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |