Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 3/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 5/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167873 | 0.88 | CRHR1 (0.45) | CRHR1ALDH1A1 | |
| SCHEMBL6167259 | 0.82 | CRHR1 (0.44) | CRHR1ALDH1A1 | |
| SCHEMBL6165056 | 0.81 | CRHR1 (0.43) | CRHR1ALDH1A1 | |
| SCHEMBL6168946 | 0.78 | CRHR1 (0.46) | CRHR1ALDH1A1CYP19A1 | |
| SCHEMBL6168505 | 0.76 | CRHR1 (0.42) | CRHR1ALDH1A1 | |
| SCHEMBL6166502 | 0.74 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6164604 | 0.74 | CRHR1 (0.41) | CRHR1ALDH1A1 | |
| SCHEMBL6166200 | 0.74 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL6174182 | 0.72 | CRHR1 (0.42) | CRHR1ALDH1A1CYP19A1 | |
| SCHEMBL6167691 | 0.72 | CRHR1 (0.65) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |