SCHEMBL6169029

SCHEMBL6169029

Nc1ccc2[nH]c(CCc3ccncc3)cc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.44
KEAP1 Q14145 1/20 0.44
IDO1 P14902 1/20 0.43
LOXL2 Q9Y4K0 4/20 0.42
HRH4 Q9H3N8 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
RAB9A P51151 3/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
F2 P00734 1/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CYP17A1 P05093 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP19A1 P11511 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ROCK2 O75116 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6169824 0.88 MAPT (0.43) IDO1LOXL2HRH4HRH3RAB9A
SCHEMBL1663549 0.76 CYP2A6 (0.50) CYP2A6KEAP1LOXL2HRH4RAB9A
SCHEMBL6252222 0.76 CYP2A6 (0.55) CYP2A6KEAP1LOXL2HRH4HRH3
SCHEMBL27978584 0.73 CYP2A6 (0.51) CYP2A6KEAP1LOXL2HRH4HRH3
SCHEMBL8812007 0.72 HRH4 (0.47) CYP2A6KEAP1IDO1HRH4HRH3
SCHEMBL28028062 0.72 HPGD (0.52) CYP2A6KEAP1HRH4ALDH1A1MAPT
SCHEMBL6252957 0.72 CYP2A6 (0.50) CYP2A6KEAP1LOXL2HRH4HRH3
SCHEMBL6252581 0.72 CYP2A6 (0.58) CYP2A6KEAP1LOXL2HRH4RAB9A
SCHEMBL28220569 0.72 CYP2A6 (0.53) CYP2A6KEAP1LOXL2HRH4RAB9A
SCHEMBL3578511 0.72 CYP2A6 (0.53) CYP2A6KEAP1LOXL2HRH4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1495016-A2 HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE Astex Technology Limited (GB) 2005-01-12 EP disclosed
WO-2003087087-A2 HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE ASTEX TECHNOLOGY LIMITED (GB) 2003-10-23 WO disclosed